Patients who are prescribed a diuretic and a renin-angiotensin system (RSA) inhibitor, such as an angiotensin converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB), to control their hypertension (high blood pressure), should avoid taking ibuprofen, according to new research published in the journal Mathematical Biosciences.Diuretics and RSA inhibitors are available by prescription under a variety of pharmaceutical brand names while painkillers such as ibuprofen are mostly available over-the-counter under different name brands such as Advil or Motrin.Researchers at the University of Waterloo looked at the interactions of diuretics, RSA, and ibuprofen using computer-simulated drug trials. The investigators found that in some patients with certain medical profiles, the combination of the three medications could cause kidney damage, which in some cases can be permanent, according to a news release.
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