Doctors may soon be able to diagnose a severe form of simply by looking at someone's face.
This type of depression, called melancholia, is marked by a complete loss of interest in daily activities and inability to respond to any pleasure, sleep problems, slow movements, speech and thoughts, agitation, restlessness, body aches and trouble with concentration.
According to researchers, about five to 10 per cent of people who are depressed have melancholia - which could represent as many as 2million Americans.
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