The sole volunteer in a trial to test an experimental and controversial gene-editing therapy has died from unknown causes.
Terry Horgan, from Montour Falls, New York, was enrolled in the study in late August with the hope of treating Duchenne muscular dystrophy (DMD).
The 27-year-old was one of the first Americans to be treated with CRISPR - which works by editing genes by precisely cutting DNA and letting the natural repair process take over.
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