When the FDA announced last month that the main ingredient in the country's favorite cold and flu meds didn't work, it was 'vindication' for the two scientists who dedicated nearly two decades to proving it was a dud. Randy Hatton and Leslie Hendeles have been warning since the 1990s that phenylephrine - found in Sudafed PE or Dayquil Cold and - was that when ingested did not enter the bloodstream to go to the nose.Dr Hendeles, an expert in pharmacokinetics, or the way medicines move throughout the body, was the first to critique phenylephrine in 1993 in a study that compared the efficacy of that and other more cold remedies including pseudoephedrine, the main ingredient of Sudafed.
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